By Harold K. Kimelberg (auth.), Philip G. Haydon, Vladimir Parpura (eds.)
Due to their loss of electric excitability, astrocytes, a subtype of glial telephone, have lengthy been ignored as lively contributors in intercellular conversation in the principal frightened process. Astrocytes, even though, own a various collection of ion channels,
neurotransmitter receptors, and shipping mechanisms that permit them to answer some of the related indications that act on neurons. Astrocytes in (Patho)Physiology of the worried method offers readers with a complete description of the physiological roles astrocytes play in regulating neuronal task and their serious involvement in
pathophysiological states of the apprehensive method, together with gliomas, Alexander's affliction, and epilepsy. This e-book may be really beneficial for researchers, scholars, and staff within the box of neurobiology and cellphone biology.
About the authors:
Vladimir Parpura, M.D., Ph.D holds either a scientific measure, presented from the college of Zagreb in Croatia in 1989, and a doctorate, acquired in Neuroscience and Zoology from Iowa country college in 1993. He has held school appointments on the division of Zoology and Genetics, Iowa country college and the dep. of cellphone Biology and Neuroscience, collage of California Riverside. he's almost immediately an affiliate Professor within the division of Neurobiology, collage of Alabama Birmingham. His present study makes a speciality of figuring out the modulation of calcium-dependent glutamate unlock from astrocytes.
Philip G. Haydon, Ph.D acquired his doctorate from the college of Leeds, England in 1982. He has held college appointments on the division of Zoology and Genetics, Iowa kingdom college, the dep. of Neuroscience on the collage of Pennsylvania, and has lately moved to Tufts college college of drugs as Professor and Chair of the dept of Neuroscience. His study specializes in the function of astrocytes within the rules of synapses, neuronal networks and behaviour in addition to how those glial cells give a contribution to neurological disorders.
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Extra resources for Astrocytes in (Patho)Physiology of the Nervous System
Ihrie, A. Alvarez- Buylla potential between two populations of GFAP-expressing cells: astrocytes derived from the adult SVZ, and astrocytes derived from the cerebral cortex. While SVZ astrocytes were able to form multipotent neurospheres or exhibit neurogenic potential under the appropriate culture conditions, astrocytes derived from the cerebral cortex lacked these capabilities. , 2004). A subpopulation of germinal zone GFAP-positive astrocytes expresses the cell-surface marker Lewis antigen (LeX), also known as CD15, a marker previously associated with SVZ neural stem cells (Capela and Temple, 2002).
Abbreviations Cm CNS EAA Er GFAP GS I–V Qt Ra Rm Rt Va Vc Vt [K+]o [K+]i Membrane capacitance Central nervous system Excitatory amino acid Reversal potential Glial fibrillary acidic protein Glutamine synthetase Current–voltage Total charge Electrode access resistance Membrane resistance Total resistance Voltage drop across R Clamp (command) potential Total voltage drop Extracellular concentration of potassium ions Intracellular concentration of potassium ions Chapter 2 Neural Stem Cells Disguised as Astrocytes Rebecca A.
Radial astrocytes (rA) have long radial processes that penetrate the granular layer as well as tangential ones that parallel this layer. These astrocytes give rise to type D immature precursors, which divide and mature into new granule neurons (G). D cells develop apical processes that become the dendrites of the new granule neurons. , 2004). It is unclear whether these astrocytes can also act as primary precursors for new neurons. , 2004). Direct targeting of the nestin-expressing cells in the SGZ, the radial astrocytes, shows that these cells generate new neurons.